| Responsible Department | Department of Agriculture and Ecology
45 % Department of Plant Biology and Biotechnology 45 % Department of Basic Animal and Veterinary Sciences 10 % | ||||||||||||||
| Earliest Possible Year | BSc. 2 year to MSc. 2 year | ||||||||||||||
| Duration | One block | ||||||||||||||
| Credits | 7.5 (ECTS) | ||||||||||||||
| Level of Course | Joint BSc and MSc | ||||||||||||||
| Examination | Final Examination written examination Written Exam in Lecturehall All aids allowed Description of Examination: A four hours written examination Weight: 100 % 7-point scale, internal examiner | ||||||||||||||
| Requirement for Attending Exam | Accepted lab reports(75 %) and oral presentation of case | ||||||||||||||
| Organisation of Teaching | Teaching includes a mix of lectures, laboratory and computer exercises complemented by cases for student groups. Laboratory work demonstrates selected key issues in plant genomics. Computer exercises demonstrate the potential of internet resources. | ||||||||||||||
| Block Placement | Block 4 Week Structure: B | ||||||||||||||
| Language of Instruction | English | ||||||||||||||
| Optional Prerequisites | 240067 | ||||||||||||||
| Restrictions | None | ||||||||||||||
| Course Content | |||||||||||||||
| Forward and reverse genetics. Gene- and genome duplication and polyploidity Mutants including: TILLING/T-DNA/transposon/spontaneous. Genome and EST sequencing programs - why particular model organisms have been chosen. Genetic diversity of plants. Phylogenetic trees, pedigrees and dendrograms based on molecular markers and gene sequences. Structure and evolution of plant genomes. Molecular marker based maps and linkage analysis. Quantitative traits and their genetics (QTL). Comparative mapping of plant genomes and the exploitation of synteny. Functional genomics. Multi gene families in plants: emphasis on cytochromes P450 and MYB transcription factors In vitro culture of plants and plant regeneration. DNA microarray expression profiling in higher plants: analysis and applications Comparative genomics and syntheny. | |||||||||||||||
| Teaching and learning Methods | |||||||||||||||
| 40 % for lectures and discussion classes. 60 % for practical exercises and supervised case studies. Students are expected to work in groups for their exercises and cases and to be able to produce written and oral presentations of their results. | |||||||||||||||
| Learning Outcome | |||||||||||||||
| The course will provide basic understanding of the structure and evolution of plant genomes and central techniques used for studies of genomes and molecular breeding through a combination of lectures, cases, wet-lab exercises and computer exercises. Focus will be on the relationship between phenotypic traits and genotypes using the expanding information and resources on plant genomes and RNA/DNA/protein sequences. The course begins with the genomics and central techniques and databases developed for the two main plant model species, rice and Arabidopsis, and translates the principles to cultivated crops to understand the potential and constraints of applying genomic technology for plant breeding. After completing the course the students should be able to: Knowledge - Describe basic principles for the study of major model plants and general plant evolution. - Classify genetic markers and their use for qualitative and quantitative traits - Describe basic central experimental techniques used in plant genomics and molecular breeding. Skills - Integrate basic knowledge on plants to understand complex biological processes using plant model systems. - Apply molecular and genetic tools for plant improvement through molecular breeding of crops for food, fodder and production of high value crops for e.g. biomedicine, biofuel, green factories, etc. Competences - Evaluate various forward and reverse genomics approaches for gene isolation and functional studies. - Relate gene differences with phenotype by means of genomics - Discuss the ethical aspects of the use of new molecular approaches in plant biotechnology e.g in relation to biodiversity. | |||||||||||||||
| Course Literature | |||||||||||||||
| Laboratory manuals, selected scientific publications, and text book | |||||||||||||||
| Course Coordinator | |||||||||||||||
| Sven Bode Andersen, sba@life.ku.dk, Department of Agriculture and Ecology/Plant and Soil Science, Phone: 353-33444 Kirsten Jørgensen, kij@life.ku.dk, Department of Plant Biology and Biotechnology/Section for Plant Biochemistry, Phone: 353-33346 | |||||||||||||||
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