| Responsible Department | Department of Plant Biology and Biotechnology
70 % Department of Agriculture and Ecology 30 % | ||||||||||||||
| Earliest Possible Year | MSc. 1 year to MSc. 2 year | ||||||||||||||
| Duration | One block | ||||||||||||||
| Credits | 7.5 (ECTS) | ||||||||||||||
| Level of Course | MSc | ||||||||||||||
| Examination | Final Examination written examination Written Exam in Lecturehall All aids allowed Description of Examination: Written Exam (4 hours) Weight: 100% 7-point scale, internal examiner Dates of Exam: 25 January 2012 | ||||||||||||||
| Organisation of Teaching | Lectures, journal clubs, colloquia. | ||||||||||||||
| Block Placement | Block 2 Week Structure: C | ||||||||||||||
| Language of Instruction | English | ||||||||||||||
| Optional Prerequisites | Knowledge of Genetics and Microbiology. | ||||||||||||||
| Course Content | |||||||||||||||
| This course provides an overview of the biology of host-microbe interactions at the molecular level. Plant diseases caused by pathogenic microorganisms are among the most important factors affecting quality and yield of crop plants. Resistance is a biological and environmentally-friendly form of plant protection depending on natural, biological defence in plants against pathogenic micro-organisms. The rapid development of biotechnology in plant science is leading to enhanced knowledge of the physiology and molecular biology of plants, and of the crosstalk between microorganisms and plants. The study of these fundamental biological processes leads not only to the improvement of strategies for disease control in plant production, but also to the discovery of molecules and genes with novel applications for industry. Topics covered include: - Bacterial pathogenicity and pathogenicity mutants; fungal pathogenicity: toxins and tissue destruction; microbial trophic strategies e.g. biotrophy, necrotrophy; symbiotic and virus interactions with plants. - Molecular and biochemical basis of plant defence mechanisms, disease resistance including secondary metabolites and antimicrobial proteins. Disease resistance through transgenic plants, new strategies for resistance breeding. - Genomics, microarrays and virus-induced silencing (VIGS). - Genetic basis of disease resistance. Plant immunity, effector molecules. Mechanisms of hypersensitive reactions (HR). - Induced resistance, Elicitation and Signal transduction pathways. - Mutants in Arabidopsis: how to understand signal transduction pathways in plant defences. - Counter adaptations: suppressors and detoxification of secondary metabolites. - Symbiosis - Microbial stress tolerance. | |||||||||||||||
| Teaching and learning Methods | |||||||||||||||
| Lectures, journal clubs, colloquia. | |||||||||||||||
| Learning Outcome | |||||||||||||||
| The course gives an understanding of the biology of plant-microbe interactions at the molecular level. After completing the course the student should be able to: Knowledge: -Give an overview of the mechanisms by which plants respond and protect themselves against pathogens. -List cellular signal transduction mechanisms in plants and microorganisms. -Describe the molecular mechanisms used by pathogens for overcoming host defences. -Have an understanding of the continuum from mutualistic symbiosis to necrotrophy. Skills: -Explain how the above topics are studied experimentally. -Interpret primary data from research articles relating to these molecular interactions and apply the knowledge to new situations in biology. Competences: -Discuss the potential of biotechnological and plant breeding technologies for developing disease resistant plants -Consider the ethical aspects of the use of different approaches (e.g. transgenic) for disease problems associated with plant protection and to put these into perspective. -See the potential for industrial processes using novel molecules derived from plant-microbe interactions. | |||||||||||||||
| Course Literature | |||||||||||||||
| Review articles and primary literature. | |||||||||||||||
| Course Coordinator | |||||||||||||||
| Mari-Anne Newman, mari@life.ku.dk, Department of Plant Biology and Biotechnology/Section for Transport Biology, Phone: 353-32581 | |||||||||||||||
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