| Responsible Department | Department of Veterinary Disease Biology
70 % Department of Basic Science and Environment 2 % Department of Basic Animal and Veterinary Sciences 28 % | ||||||||||||||||||||
| Earliest Possible Year | MSc. 2 year | ||||||||||||||||||||
| Duration | Two blocks | ||||||||||||||||||||
| Credits | 26.5 (ECTS) | ||||||||||||||||||||
| Level of Course | MSc | ||||||||||||||||||||
| Examination | Continuous Assessment oral examination Practical Examination Some Aid allowed Limited Aid allowed in the preparation period Description of Examination: Oral examination in practical and theoretical skills and oral presentation of a poster prepared on the basis of own experimental data obtained during the course. Passing the exam in experimental animal sciences provides FELASA authorisation category 'C' 7-point scale, internal examiner | ||||||||||||||||||||
| Block Placement | Block 3 Week Structure: Outside schedule Block 4 Week Structure: Outside schedule | ||||||||||||||||||||
| Language of Instruction | English | ||||||||||||||||||||
| Restrictions | 36. Forbeholdt veterinærstuderende. | ||||||||||||||||||||
| Course Content | |||||||||||||||||||||
| The course includes modules of laboratory animal science, experimental design and risk assessment, in vivo pharmacology and toxicology and histopathology relevant to laboratory animal experimentation as well as a range of laboratory methods complementing in vivo experiments. It also includes molecular biological methods used for research within the area of pro- and eukaryote genomics. Other topics covered are modern diagnostic methods, typing methods, antibiotic resistance, molecular methods and strategies for studies of host pathogen interaction, evolution of pathogens, vaccinology, surveillance and outbreak investigations and the immune system in relation to infections. The laboratory animal science part of the course has been accredited by the Danish Ministry of Justice and by the Federation of European Laboratory Animal Associations as adequate for those acquiring a permit for performing animal experiments. | |||||||||||||||||||||
| Teaching and learning Methods | |||||||||||||||||||||
| The differentiation consists of both theoretical and practical teaching. | |||||||||||||||||||||
| Learning Outcome | |||||||||||||||||||||
| The aim of the course is to provide the students with work-relevant competences and qualifications required to design, perform and evaluate laboratory animal experiments in biomedical research and product development. Moreover, it provides the students with a thorough knowledge on methodologies of clinical microbiology, parasitology, genetics and clinical as well as molecular pathology and the role of these subjects when applied in pharmaceutical industry in relation to development of new antibiotics and vaccines and in general control and prevention measures. Learning outcomes Having completed the course, the student should be able to: Knowledge . Describe modern diagnostic methods and principles. . Summarize rules and regulations, principles, methods and terminology relevant for the planning, execution and evaluation of experimental animal work . Describe inference methods and risk analysis . Describe mechanisms of antibiotic and anthelmintic resistance and host interaction and reflect on the clinical and public health relevance. . Give an overview of the most important national and international surveillance systems for infectious diseases and antibiotic resistance . Describe the principles of vaccine development and effects of use of vaccines. . Describe methods and strategies commonly used to determine virulence factors. . Describe the structure and function of the mammalian and prokaryote genome . Summarize the main issues in relation to genetic mapping of qualitative and quantitative traits. . Describe and perform main molecular biological methods. . Understand and provide a critical evaluation of literature describing subjects within the area of biomedicine Skills . Explain and assess strengths and weaknesses of the commonly used laboratory methods in clinical microbiology, parasitology and pathology and be able to select the right method for the right purpose . Explain basic principles in biomedical research . Evaluate the use of in vitro and in vivo methodology in research and development . Use basic statistical and inference methods. Evaluate histological lesions and reactions in laboratory animals. . Use basic surgical methods in laboratory animal science . Explain how to address and/or counteract common causes of mis- classification in clinical microbiological, parasitological and pathological tests . Critical ability to read results of laboratory analysis and communicate results . Design a quality assurance program for diagnostic procedures . Determine antibiotic resistance both by quantitative and qualitative methods including specialized procedures . Design an investigation of which gene is responsible for antibiotic resistance in a bacteria . Evaluate which molecular genetic techniques are relevant for the study of a given genetic problem . Analyse and evaluate results from simple diagnostic tests in mammals . Be able to discuss professional and scientific problems in relation to biomedical topics both with colleagues and non-specialists Competences . Work independently with problem solving in clinical microbiology and clinical pathology . Be able to identify virulence factors of microorganisms and parasites . Use knowledge on virulence factors in development of methods to control infections, e.g. in the form of active and passive immunizations and new drugs . Discuss the use of animals and in vitro methods in research and product development . Use theoretical and practical methodology in laboratory experiments employing live animals . Critically evaluate experiments . Be able to find new information/literature on topics within the area of biomedicine . Be able to take responsibility for own professional development and specialization. | |||||||||||||||||||||
| Course Coordinator | |||||||||||||||||||||
| Jens Lykkesfeldt, jopl@life.ku.dk, Department of Veterinary Disease Biology/Section for Biomedicine, Phone: 353-33163 Merete Fredholm, mf@life.ku.dk, Department of Basic Animal and Veterinary Sciences/Genetics & Bioinformatics, Phone: 353-33074 John Elmerdahl Olsen, jeo@life.ku.dk, Department of Veterinary Disease Biology/Section for Microbiology, Phone: 353-32784 Dorte Bratbo Sørensen, dobj@life.ku.dk, Department of Veterinary Disease Biology/Section for Biomedicine, Phone: 353-32724 | |||||||||||||||||||||
| Study Board | |||||||||||||||||||||
| Study Committee V | |||||||||||||||||||||
| Work Load | |||||||||||||||||||||
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